GTI
Glucocorticoid Toxicity Index

Clinical Science

The Research Behind GTI 2.0

Enter a new era of steroid-sparing research, 70 years after steroids were first introduced
1948
First clinical use of glucocorticoids
23 days later…
First report of toxicity described
2018
The first and only glucocorticoid toxicity index (GTI) is introduced - weighted and standardized to measure steroid safety

The Glucocorticoid Toxicity Index (GTI) was developed through an expert consensus approach using multi-criteria decision analysis. The 20 medical experts who participated in the development of the GTI are international authorities in their respective subspecialties, representing rheumatology, pulmonary medicine, nephrology, neurology, psychiatry, dermatology, maternal-fetal medicine, and infectious disease.

The GTI was created by experts in several sub-specialities and is based on data-driven, peer-reviewed research.
February 2021: Avacopan for the Treatment of ANCA-Associated Vasculitis
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January 2021: The Role of Quantification of Glucocorticoid-associated Toxicity in Severe Asthma
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January 2021: The Vexed Problem of Corticosteroid Toxicity in Asthma: Time for Standardized Assessment
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2016: Development of a Glucocorticoid Toxicity Index (GTI 1.0) Using Multicriteria Decision Analysis
GTI PDF
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