GTI
Glucocorticoid Toxicity Index

Why GTI 2.0?

Don't let steroid toxicity be a blindspot in your next clinical trial.

The weighted outcome measure that scores change in steroid toxicity over time.

GTI 2.0 delivers two scores that accurately measure toxicity over time: the Aggregate Improvement Score (AIS) and the Cumulative Worsening Score (CWS). Taken together, the AIS and CWS provide a nuanced view of glucocorticoid toxicity. The first and only weighted outcome measure that scores the change in steroid toxicity over time. Steroid-sparing agents that minimize the need for long-term glucocorticoid therapy are associated with lower GTI scores.

Benefits of using GTI

Benefit For You
Benefit For Your Patient
Balances Rigor with Ease Of Use Balances Rigor with Ease Of Use
Benefit For You
The GTI balances rigor with ease of use. More than half of the reporting is done by the trial coordinator.
Benefit For Your Patient
The app takes care of the details so the clinician can take care of the patient.
Saves Time Saves Time
Benefit For You
The GTI avoids redundancy in data capture, permitting crosstalk between elements of the trial database.
Benefit For Your Patient
Less screen time for clinicians allows for more time with the patient.
Ensures Accuracy Ensures Accuracy
Benefit For You
The GTI facilitates a high level of accuracy, with prompts each step of the way.
Benefit For Your Patient
The patient has the undivided attention of the physician, while the app calculates accuracy throughout the visit.

Using GTI to evaluate steroid toxicity

Cumulative Worsening Score (CWS)
For trials in some diseases, it may be most important to document ANY cumulative GC toxicity that occurs. The CWS assesses cumulative toxicity, both permanent and transient. The CWS serves as a record of worsening toxicity.
Aggregate Improvement Score (AIS)
With AIS, baseline toxicities that resolve are removed from the score. Newly-occurring toxicities are added to the score.
01
Record baseline data at patients' first visit.
02
Records follow up data at defined intervals.
03
Access realtime scores at each interval and receive final scores at the close of trial.