The weighted outcome measure that scores change in steroid toxicity over time.
GTI 2.0 delivers two scores that accurately measure toxicity over time: the Aggregate Improvement Score (AIS) and the Cumulative Worsening Score (CWS). Taken together, the AIS and CWS provide a nuanced view of glucocorticoid toxicity and help make the case for the safety of new steroid-sparing treatments. The first and only weighted outcome measure that scores the change in steroid toxicity over time. Steroid-sparing agents that minimize the need for long-term glucocorticoid therapy are associated with lower GTI scores and improved safety.